Frequently Asked Questions

Live Chat and  Frequently Asked Questions  are available for this Product.

Application

Streptozocin is used to induce Type 1 diabetes for medical research.

General description

Streptozotocin, a glucosamine-nitrosourea, is a DNA alkylating agent that enters cells exclusively via the GLUT2 glucose transport protein. Streptozocin, a diabetagen, is especially toxic to pancreatic islet insulin-producing β-cells. It is toxic to GLUT2 positive neuroendocrine tumor cells.

Other Notes

Mixed anomers

包装

1, 5 g in glass bottle

100, 500 mg in glass bottle

50 mg in poly bottle

Biochem/physiol Actions

An N-nitroso-containing compound that acts as a nitric oxide donor in pancreatic islets; induces death of insulin-secreting cells, producing an animal model of diabetes. Potent DNA methylating agent that induces chromosomal breakage.¹  Cytotoxic to neuroendocrine tumor cell lines that express the GLUT2 glucose transporter.